DM Newman, CL Sake, AJ Metcalf, FK Davies and NR Boyle. “Characterizing Photosynthetic Biofuel Production: Isotopically non-stationary 13C metabolic flux analysis (INST-13CMFA) on limonene producing Synechococcus sp. PCC 7002.” Frontiers in Energy Reseacrh.

AJ Metcalf and NR Boyle. “Rhythm of the Night (and Day): Predictive metabolic modeling of circadian growth in Chlamydomonas.” mSystems.

CL Sake, AJ Metcalf, M Meagher, Jorge Di Paola, KB Neeves, and NR Boyle. “Isotopically Nonstationary 13C Metabolic Flux Analysis in Resting and Activated Human Platelets.” Metabolic Engineering.


AJ Metcalf, A Nagygyor and NR Boyle. “Rapid Annotation of Photosynthetic Systems (RAPS): automated algorithm to generate genome-scale metabolic networks from algal genomes”. Algal Research. 2020, v50.

CL Sake, DM Newman and NR Boyle. “Evaluation of Quenching Methods for Metabolite Recovery in Photoautotrophic Synechococcus sp. PCC 7002”. Biotechnology Progress. 2020. e3015.


JJ Gardner, Bri-Mathias S. Hodge, and NR Boyle. “Multiscale Multiobjective Systems Analysis (MiMoSA): an advanced metabolic modeling framework for complex systems”. Nature Scientific Reports. 2019, 9 (1) 16948.

CL Sake, AJ Metcalf, and NR Boyle. “The Challenge and Potential of Photosynthesis: Unique Considerations for Metabolic Flux Measurements in Photosynthetic Microorganisms.” Biotechnology Letters. 2018, 41 (1) 35-45.


JJ Gardner and NR Boyle. “The use of a genome-scale metabolic network reconstruction to predict fluxes and equilibrium composition of N-fixing versus C-fixing cells in a diazotrophic cyanobacterium, Trichodesmium erythraeum.” BMC Systems Biology. 2017, 11(1).

NR Boyle*, N Sengupta and JA Morgan. “Metabolic Flux Analysis of Heterotrophic Growth in Chlamydomonas reinhardtii”. PLOS One. 2017, 12(5).


M Liberatore, BN Peterson, T Nottoli, JM McCulloch, RE Jinkerson, NR Boyle, MC Posewitz. “Effectiveness of cationically modified cellulose polymers for dewatering algae.” Separation Science. 2016, 51 (5) P: 892-898.


CJ Ramey, Á Barón-Sola, HR Aucion, NR Boyle. “Genome Engineering in Cyanobacteria: Where we are and where we need to go.” ACS Synthetic Biology. 2015, 4(11) p:1186-1196.

RI Zeitoun, AD Garst, GD Degen, G Pines, TY Glebes, NR Boyle and RT Gill. “Multiplexed Tracking of the Evolutionary Trajectory of Combinatorial Genome Engineered Populations”. Nature Biotechnology. 2015, 33 p:631 – 637.


S Schmollinger1, T Mühlhaus1, NR Boyle1, IK Blaby, D Casero, T Mettler, J Kropat, F Sommer, D Hemme, M Stitt, M Pellegrini, M Schroda, SS Merchant. “Systems analysis of nitrogen sparing mechanisms in Chlamydomonas reinhardtii”. The Plant Cell. 2014, 26(4) 1410 – 1435.


IK Blaby, AG Glaesener, T Mettler, S Fitz-Gibbon, S Gallaher, B Liu, NR Boyle, J Kropat, M Stitt, S Johnson, C Benning, M Pellegrini, D Casero, SS Merchant. “Systems-level analysis of N-starvation induced TAG accumulation in a Chlamydomonas starchless mutant”. The Plant Cell. 2013, 25(11) p: 4305-4323.

NR Boyle, TS Reynolds, R Evans, M Lynch, and RT Gill. “Recombineering to Homogeneity: Extension of Multiplex Recombineering to Large-Scale Genome Editing”. Biotechnology Journal. 2013, 8(5) p: 515-522.

LBA Woodruff, NR Boyle, RT Gill. “A directed, genome-wide approach to select for improved ethanol production in a heterologous Escherichia coli production platform”. Metabolic Engineering. 2013, 17(0) p: 1-11.

EC Spindler, NR Boyle, REW Hancock, RT Gill. “Genome-wide identification of genes conferring energy related resistance to a synthetic antimicrobial peptide (Bac8c)”. PLoS ONE. 2013, 8(1): e55052.


NR Boyle, RT Gill. “Tools for Genome-Wide Strain Design and Construction”. Current Opinion in Biotechnology. 2012, 23(5): p 666-671.

NR Boyle, MLD Page, B Liu, IK Blaby, J Kropat, S Cokus, S Karpowicz, D Casero, J Shaw, A Hong-Hermesdorf, S Johnson, C Benning,M Pellegrini, A Grossman, S Merchant. “Three acyltransferases and a nitrogen responsive regulator are implicated in nitrogen starvation-induced triacylglycerol accumulation in Chlamydomonas reinhardtii”. Journal of Biological Chemistry. 2012, 287(19): p 15811-15825.


NR Boyle, JA Morgan. “Computation of Metabolic Fluxes and Efficiencies for Biological Carbon Dioxide Fixation”. Metabolic Engineering. 2011, 13(2): p 150-158.


NR Boyle, JA Morgan. “Flux balance analysis of primary metabolism in Chlamydomonas reinhardtii”. BMC Systems Biology. 2009, 3(1):4. [Highly Accessed]

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